Subsequent dissection of functional consequences of common AMD-linked polymorphisms led to the concept of the ‘complotype’ -the influence of complement genetic makeup on inflammation & infection. With collaborators in Madrid, she was the first to characterise ‘gain-of-function’ mutations in the complement activating proteins, C3 and factor B, explaining their association with renal disease. She has a keen interest in structure-function relationships in complement activators and regulators with a particular focus in the mechanisms underlying complement dysregulation and disease. She has been studying complement for more than 30 years with experience in both academia and Pharma. ![]() Professor of Molecular Immunology, Newcastle University, UKĬlaire Harris is Professor of Molecular Immunology at Newcastle University.
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